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The increased risk may be of particular relevance when these drugs are associated with nonsteroidal anti-inflammatory drugs.
Two placebo-controlled studies in 766 pediatric patients with MDD have been conducted with venlafaxine hydrochloride extended-release capsules, and the data were not sufficient to support a claim for use in pediatric patients.
These side effects may go away during treatment as your body adjusts to the medicine.
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They did, however, state that this type of data is open to criticism pointing out that mortality data may be influenced by previous literature and that "less toxic" drugs may be preferentially prescribed to patients at higher risk of poisoning and suicide but they are also less likely to be listed as the sole cause of death from overdose.
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Given the decrease in clearance and increase in elimination half-life for both venlafaxine and ODV that is observed in patients with hepatic cirrhosis and mild and moderate hepatic impairment compared to normal subjects (see ), it is recommended that the total daily dose be reduced by 50% in patients with mild to moderate hepatic impairment.
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Evaluation of the electrocardiograms for 769 patients who received venlafaxine hydrochloride in 4- to 6-week double-blind placebo-controlled trials, however, showed that the incidence of trial-emergent conduction abnormalities did not differ from that with placebo.
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Consider monitoring serum cholesterol concentrations during long-term treatment.
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Adequate time is necessary for exposure through behavioral therapy to minimize or eradicate agoraphobic avoidance.
There were no statistically significant changes in plasma levels of SSRIs (paroxetine and fluoxetine) during the trial.
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Approximately 87% of a venlafaxine dose is recovered in the urine within 48 hours as either unchanged venlafaxine (5%), unconjugated ODV (29%), conjugated ODV (26%), or other minor inactive metabolites (27%).
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Emergence of adverse events following discontinuation of treatment with extended-release venlafaxine".
However, co-administration of cimetidine had no apparent effect on the pharmacokinetics of ODV, which is present in much greater quantity in the circulation than is Venlafaxine.
It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop.
Other studies have failed to support either an overall difference in suicide risk between antidepressant- and placebo-treated depressed individuals or a difference between SSRIs and either other types of antidepressants or placebo.
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